Nucleoside Analogs

Nucleoside analogs have many potential applications in the pharmaceutical industry including the biotechnology area. Nucleoside analogs already offer breakthrough treatment in macular degeneration. This is the only treatment option for this ophthalmologic disease. Nucleoside analog are expected to play a pivotal role in the future therapy for many disease areas such as autoimmune diseases and cancer. Sapala has prepared many nucleoside analogs and built expertise in nucleoside chemistry since the beginning of the operation. Sapala has extensive experience in making unnatural sugars, modified bases, and modified nucleosides Nucleoside analogs with high purity have wide applications toward new therapeutic agents. Sapala has also developed multi-gram scale synthetic processes of nucleoside analogs in pure form.

  • Fluoro substituted nucleoside analogs
  • Ether derivatives of natural nucleoside analogs
  • Methyl substituted nucleoside analogs
  • Α-nucleoside analogs
  • Dideoxy nucleoside analogs
  • Mercapto derivative of nucleoside analogs
  • Carbocyclic nucleoside analogs
  • Various base modified nucleoside analogs

Orthogonally protected carbohydrate building blocks and bicyclo intermediates are available for new nucleoside analog synthesis.

Representative examples are as follows:

Product No. Structure IUPAC Name CAS No. Specification & MSDS
SNS-0001 Nucleoside analogs 3'Deoxy adenosine (or) Cordycepin 73-03-3   Ether derivatives of natural nucleoside analogs
SNS-0002 Methyl substituted nucleoside analogs 1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione --------  Dideoxy nucleoside analogs
SNS-0003 Fluoro substituted nucleoside analogs 1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione --------  Carbocyclic nucleoside analogs
SNS-0004 nucleoside chemistry 4-Amino-1-(3-hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one --------   pharmaceutical industry including the biotechnology area
SNS-0005 Contract Research Organization specializing in custom synthesis of Organic Compounds N-[1-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl] -------- active pharmaceutical ingredients, drug intermediates, fine chemicals, CRO companies 
SNS-0006 contact research organization, has well-built ability in organic synthesis 2-(6-Amino-purin-9-yl)-5-hydroxymethyl-4-methoxy-tetrahydro-furan-3-ol -------- heterocyles for pharma intermediates, natural or unnatural nucleosides and their analogs 
SNS-0007 Ru complexes for photovoltaic study N-[9-(3-Hydroxy-5-hydroxymethyl-4-methoxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide --------   RCM and transition metal catalysed reaction
SNS-0008 talented scientists and developed excellent skills and knowledge in organic synthesis 1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione --------   Structure Activity Relation studies
SNS-0009 Bioorganic and Medicinal Chemistry 1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione -------- cyclopropyl derivatives 
SNS-0010 cyclohexylamine derivatives 4-Amino-1-(4-fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one --------   thiophene, indole, Pyrazole, pyrimidine
SNS-0011 Phenanthrolines are a bidentate ligand N-[1-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide --------   bipyridine and terpyridine derivatives
SNS-0012 ruthenium dye synthesis 2-(6-Amino-purin-9-yl)-4-fluoro-5-hydroxymethyl-tetrahydro-furan-3-ol --------   heteroaryl Pinacol boronates
SNS-0013 pyrimidyl, thiazolyl, isothiazolyl N-[9-(4-Fluoro-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide --------   thiophene, indole, Pyrazole, pyrimidine
SNS-0014 Cyclohexanone derivatives 4-Amino-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one -------- carboxylic acid or amine 
SNS-0015 piperidone nitrogen atom N-[1-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide --------   Thidiazoles heterocyclic compounds
SNS-0016 alkylation on azetidine nitrogen 5-(6-Amino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol --------   boronate of oxazole, thiazole, imidazole and benzimidazole
SNS-0017 analytical services N-[9-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide --------   Synthesis of Dyes for photo-functional applications
SNS-0018 Drugs and its intermediate synthesis [5-(6-Amino-purin-9-yl)-tetrahydro-furan-2-yl]-methanol --------   Chemical Technology and Center for Cellular and Molecular Biology
SNS-0019 organic chemistry 1-(5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione -------- photocycloaddition reaction 
SNS-0020 porphyrins and phthalocyanines 1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione --------   gycosylation techniques
SNS-0021 Biotransformation 1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione --------  nalytical method development and validation
SNS-0022 Organic Synthesis 4-Amino-1-(3,4-dihydroxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one --------  Contract Research
SNS-0023 analytical services N-[1-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide --------   Contract Research organisation cro
SNS-0024 cyclohexanone derivatives 2-(6-Amino-purin-9-yl)-tetrahydro-furan-3,4-diol --------  Pyrazole, pyrimidine
SNS-0025 ruthenium dyes N-[9-(3,4-Dihydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide --------  
SNS-0026 halide under Suzuki coupling conditions 1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione --------   Library molecules for SAR studies
SNS-0027 Catalysis and Dye Sensitized Solar Cells 1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione --------   Preparative HPLC - Jasco 2000, UV-2075
SNS-0028 Aryl halide or vinyl halide 4-Amino-1-(3,4-dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one --------   Sapala is capable of executing any type of organic reactions
SNS-0029 RCM and transition metal catalysed reaction N-[1-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-
yl]-benzamide		 --------   heteroaromatic boronates for Suzuki coupling reaction
SNS-0030 nucleoside analog synthesis 2-(6-Amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol -------- nucleoside chemistry 
SNS-0031 Industrial Research Organizations N-[9-(3,4-Dihydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide --------   Gas chromatography
SNS-0032 LCMS and Mass ((5R,6S)-6-methoxy-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate --------   Specific optical rotation
SNS-0033 track-record in implementing Contract Research Projects (3R,4S,5R)-5-(benzoyloxymethyl)-4-methoxy-tetrahydrofuran-2,3-diyl dibenzoate -------- synthetic processes of nucleoside analogs in pure form