Cyclopropyl derivatives

A cyclopropyl group has been widely used to build SAR in medicinal chemistry. A cyclopropyl group is considered as an isostere of olefin (Bioorganic and Medicinal Chemistry Letter, 1996, 6(2), 213-218).

A cyclopropyl group could be used in SAR studies in place of a geminal-dimethyl group or a geminal-difluoro group.

A cyclopropyl group may provide metabolic stability because of its inherent bond angle.

However, the commercial availability of properly functionalized cyclopropyl derivatives is very limited. We have developed synthetic methods for a varieties of 1,1-disubstituted cyclopropyl derivatives anticipating their use in medicinal chemistry both in industry and academia. One substituent is an aryl group including heteroaryl, and other substituent is a polar functional group such as carboxylic acid, nitrile, amino, phenylcarbamate etc.

All these cyclopropyl derivatives are available in miligram to gram quantity. An order for a higher amount can be taken upon request.

The cyclopropyl moiety with carboxylic acid or amine could be used to construct amide bond. The cyclopropyl synthon with phenyl carbamate is a suitable precursor for isocyante for the synthesis of urea derivatives. Where as cyclopropyl derivatives with nitrile and imidamide could be used for the synthesis of complex heterocyclic ring or could be used in multicomponent reaction.

All our cyclopropyl synthons have low to medium molecular weights and contain only one reactive functional group and has no chiral center.

Product No. Structure IUPAC Name CAS No. Specification & MSDS
SCP-0001 cyclopropyl derivatives synthons have low to medium molecular weights 1-(2-Chlorophenyl) cyclopropane carboxylicacid 122143-19-5 cyclopropyl moiety with carboxylic acid or amine could be used to construct amide bond
SCP-0002 active pharmaceutical ingredients, drug intermediates, fine chemicals, CRO companies and other chemical manufacturing companies 1-(3-Chlorophenyl) cyclopropane carboxylicacid 124276-34-2 Contract Research Organization specializing in custom synthesis of Organic Compounds
SCP-0003 Sapala is capable of executing any type of organic reactions and also has accumulated knowledge and experiences in purification 1-(4-Chlorophenyl) cyclopropane carboxylicacid 72934-37-3 synthetic routes to make polypyridines with high purity in a semi-bulk scale and their Ru complexes for photovoltaic study
SCP-0004 Photochemical reactions 1-(2-Fluorophenyl) cyclopropane carboxylicacid 306298-00-0 Enzymatic reaction
SCP-0005 RCM and transition metal catalysed reaction 1-(3-Fluorophenyl) cyclopropane carboxylicacid 248588-33-2 Synthesis of cage molecule
SCP-0006 Dendrimer synthesis 1-(3-(Trifluoromethyl)phenyl) cyclopropane carboxylicacid -------- Polymer modifications
SCP-0007 new heteroaromatic boronates for Suzuki coupling reaction 1-(Pyridin-2-yl)cyclopropane carboxylicacid 162960-26-1 carboxylic acid and nitrile
SCP-0008 1-(Pyridin-3-yl)cyclopropane carboxylicacid -------- Structure Activity Relation studies
SCP-0009 Development and Validation of analytical methods 1-(Pyridin-4-yl)cyclopropane carboxylicacid -------- Biotransformation
SCP-0010 Drugs and its intermediate synthesis 1-(2-(Trifluoromethyl)phenyl) cyclopropane carbonitrile -------- Analytical method development and validation
SCP-0011 Biotransformation process involving multi-gram scale enzymatic oxidation 1-(3-(Trifluoromethyl)phenyl) cyclopropane carbonitrile -------- Nucleoside chemistry involving the synthesis of a variety of nucleosides
SCP-0012 Phenanthrolines are a bidentate ligand with similar coordination properties to 2,2’-bipyridines 1-(4-(Trifluoromethyl)phenyl) cyclopropane carbonitrile -------- phenanthroline followed by titration with alcohols to a colourless endp
SCP-0013 heteroaryl Pinacol boronates such as pyrimidyl, thiazolyl, isothiazolyl 1-(2-Chlorophenyl) cyclopropane carbonitrile 122143-18-4 Heteroaryl moieties are present in many APIs and also in natural produ
SCP-0014 1-(4-Chlorophenyl) cyclopropane carbonitrile 64399-27-5
SCP-0015 cyclohexanone derivatives are useful building blocks in medicinal chemistry 1-(2-Fluorophenyl) cyclopropane carbonitrile 97009-38-6 scalable routes and prepared various 4,4-disubstitute cyclohexanone derivatives
SCP-0016 cyclopropyl synthons have low to medium molecular weights 1-(3-Fluorophenyl) cyclopropane carbonitrile 124276-55-7 cyclopropyl synthon with phenyl carbamate is a suitable precursor for isocyante for the synthesis of urea derivatives
SCP-0017 alkyl lithium content of solutions 1-(4-Fluorophenyl) cyclopropane carbonitrile 97009-67-1 Contract Research Projects from Industrial Research Organizations and academia - universities
SCP-0018 simple purification methods for ruthenium dyes 1-(Pyridin-2-yl) cyclopropanamine. dihydrochloride -------- ultra pure ruthenium dye and scale-up are the major challenges for this technology
SCP-0019 Photovoltaic solar cell technology 1-(Pyridin-3-yl) cyclopropanamine. dihydrochloride -------- dye sensitized solar cell brought revolution in renewable energy technology